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Major depression and generalized anxiety disorder among HTLV-I/II infected former blood donors

Authors
Journal
Retrovirology
1742-4690
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
8
Identifiers
DOI: 10.1186/1742-4690-8-s1-a70
Keywords
  • Meeting Abstract
Disciplines
  • Education
  • Medicine

Abstract

Major depression and generalized anxiety disorder among HTLV-I/II infected former blood donors MEETING ABSTRACT Open Access Major depression and generalized anxiety disorder among HTLV-I/II infected former blood donors Anne M Guiltinan1*, Zhanna Kaidarova1, Dee Behan2, Cheryl Marosi3, Sheila Hutching4, Mandi Kaiser5, Elane Moore5, Deborah DeVita1,6, Edward L Murphy1,6* From 15th International Conference on Human Retroviruses: HTLV and Related Viruses Leuven and Gembloux, Belgium. 5-8 June 2011 Background Other studies have reported high rates of depression and anxiety among human T-lymphotropic virus type 1 (HTLV-1) infected subjects, and have even suggested that HTLV-I causes psychiatric disease. Methods We interviewed HTLV-I, HTLV-II and demographically similar HTLV seronegative blood donors with the Mini- International Neuropsychiatric Interview (MINI). Preva- lences of major depression and generalized anxiety dis- order in each group were calculated and compared to published U.S. population data. Adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) controlling for educational achievement, alcohol intake and self- reported health status were calculated with multivariate logistic regression. Results Major depression was diagnosed in 5 (5.4%) of 93 HTLV-I positive subjects (aOR = 2.19, 95% CI 0.63- 7.55) and 17 (6.6%) of 256 HTLV-II positive subjects (aOR = 1.61, 95% CI 0.66-3.92), compared to 12 (2.1%) of 585 HTLV seronegative blood donors. The prevalence of major depression among infected subjects was com- parable to the 6.7% prevalence in the U.S. general popu- lation. Generalized anxiety disorder was diagnosed in 5 (5.4%) HTLV-I positive subjects (OR= 2.32, 95% CI 0.74-7.26) and 12 (4.7%) HTLV-II positive subjects (OR = 1.65 95% CI 0.68-4.01), compared to 15 (2.6%) serone- gatives and 3.1% in the U.S. general population. Conclusion We observed slightly higher prevalence of major depres- sion and generalized anxiety disorder among HTLV-I and HTLV-II subjects

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