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Is Alzheimer's a homogeneous disease, Are plaques critical and Does the blood brain barrier really contribute?

Authors
Journal
Neurobiology of Aging
0197-4580
Publisher
Elsevier
Publication Date
Volume
7
Issue
6
Identifiers
DOI: 10.1016/0197-4580(86)90092-8
Disciplines
  • Medicine

Abstract

Abstract Several problems exist with the speculative hypothesis presented. The relationship between neuritic plaques and clinical symptoms is not well established and is further complicated by the likely existence of multiple subforms of Alzheimer's disease. Moreover, direct support for changes in the blood brain barrier with Alzheimer's disease is lacking, and the available circumstantial evidence argues against it having an important role in the pathogenesis of the disease.

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