Abstract Pain threshold/tolerance and vibration perception were studied in a sample of female frequent and infrequent cannabis users. Interactions with personality characteristics were examined using the EPI. Performance on all measures was investigated after oral administration of either 10mgΔ 9 THC or 20 mg Δ 9 THC. Results indicated that while the 10mg dosage produced no consistent changes in cutaneous sensory response, the 20 mg dosage was followed by lowering of the vibration threshold. Frequent and infrequent cannabis users differed in their response to the pain stimulus (pain tolerance scores were higher among infrequent users). They also differed with respect to the personality measure (frequent users had lower E, N and L scores). The findings provide experimental support for cannabis users' reports of enhanced sensory awareness consequent to drug intake. The results also show that frequent and infrequent cannabis users differ in pain response and personality characteristics.