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Iodo- and bromodeoxyuridine are excised at different rates from DNA of mouse tongue keratinocytes in vitro

Authors
Journal
Chemico-Biological Interactions
0009-2797
Publisher
Elsevier
Publication Date
Volume
60
Issue
2
Identifiers
DOI: 10.1016/0009-2797(86)90031-1
Keywords
  • Iododeoxyuridine - Bromodeoxyuridine - Dna Repair - In Vitro - Tongue - Keratinocytes
Disciplines
  • Biology

Abstract

Abstract The development of antibodies to iododeoxyuridine (IdU) and bromodeoxyuridine (BrdU) has increased interest in the use of these compounds in cell biology. However, little is known about their metabolism in vivo and in vitro. In this paper we show that, contrary to the impression gained from earlier studies, these compounds are not stably incorporated into DNA of mouse tongue epithelial cells in vitro but are removed, with turnover times of 1.0 days (BrdU) and 3.8 days (IdU).

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