Affordable Access

Publisher Website

Evaluation of vitamin E in the treatment of erectile dysfunction in aged rats

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
90
Identifiers
DOI: 10.1016/j.lfs.2011.12.019
Keywords
  • Vitamin E
  • Antioxidant Therapy
  • Sildenafil
  • Aging
  • Erectile Dysfunction
Disciplines
  • Medicine

Abstract

Abstract Aims The present study aims to elucidate the role of oxidative stress in erectile dysfunction associated with aging and to investigate the effect of treatment with vitamin E in this respect. Main methods Rats were divided into four groups: young (3-month-old), aged rats (18-month-old), aged rats given 80IU of vitamin E/rat/day for 21-days, aged rats given 5mg/kg of sildenafil/day for 21-days. Intracavernosal pressure/mean arterial pressure (ICP/MAP), nitric oxide production, TBARS, GSH levels and SOD activity in corpus cavernosum were measured. Key findings Significant decrease in ICP/MAP was observed in aged rats at both low and high frequency of stimulation. Significant increase in ICP/MAP was observed in aged rats treated with vitamin E over the range of 0.8 to 5Hz but young control values were not restored. Percentage potentiation of ICP/MAP than aged group at 0.8Hz was 326±41.3% and 897±72.2% for vitamin E and sildenafil respectively. Decreased levels of NO2/NO3 and SOD activity in the penile tissue observed with aging were elevated back to control by either vitamin E or sildenafil. Penile concentration of TBARS was 20.86±0.83 for aged rats vs. 11.39±0.79nmol/g tissue for young controls. Both vitamin E and sildenafil reduced penile TBARS in aged rats. Significance This study proves that antioxidant therapy with vitamin E ameliorates the age-associated erectile dysfunction. Sildenafil may exert some antioxidant properties which add to the advantages of its long-term use. The effect of combinations of low-dose sildenafil and vitamin E on age-associated erectile dysfunction merits to be studied.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Erectile failure in the aged: evaluation and treat...

on Journal of the American Geriat... January 1988

Evaluation and treatment of erectile dysfunction.

on American family physician May 01, 1996

Evaluation and treatment of erectile dysfunction.

on The American Journal of the Me... February 1995

Evaluation and Treatment of Erectile Dysfunction

on Medical Clinics of North Ameri... Jan 01, 2011
More articles like this..