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Platelets process adsorbed protein: a morphological study

Authors
Journal
Biomaterials
0142-9612
Publisher
Elsevier
Publication Date
Volume
12
Issue
6
Identifiers
DOI: 10.1016/0142-9612(91)90058-i
Keywords
  • Fibrinogen
  • Fibronectin
  • Platelet Adhesion
Disciplines
  • Biology

Abstract

Abstract The nature of the adsorbed protein on a non-biological biomaterial surface is known to influence cell adhesion. This work deals with the contribution of adherent platelets towards the redistribution of pre-adsorbed proteins. A redistribution was only observed with spread platelets on adsorbed fibrinogen and fibronectin, but not with adsorbed beta-lactoglobulin. The labelled protein images showed a dark outer ring with an inner region having fluorescent areas, with greater intensity than regions not covered by platelets. The fluorescent patterns observed may be a result of the binding of adsorbed fluorescent protein to the glycoprotein llb/llla receptors of platelets, followed by their redistribution within the plasma membrane.

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