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Photochemically mediated ring contraction of pyrazolidin-3-ones to β-lactams

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
3
Issue
11
Identifiers
DOI: 10.1016/s0960-894x(01)80960-4
Disciplines
  • Chemistry

Abstract

Ring contraction routes to β-lactams are surveyed. Methodology based on photochemically mediated contraction of pyrazolidin-3-ones ( 1) is presented which affords azetidin-2-ones ( 2). The latter can be converted to precursors of β-lactam antibiotics, including PS-5 and monobactam analogues.

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