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Effects of atrazine on sex steroid dynamics, plasma vitellogenin concentration and gonad development in adult goldfish (Carassius auratus)

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Keywords
  • Atrazine
  • Carassius Auratus
  • Endocrine Disruption
  • Sex Steroids
  • Life Sciences :: Aquatic Sciences & Oceanology [F04]
  • Sciences Du Vivant :: Sciences Aquatiques & Océanologie [F04]
  • Life Sciences :: Environmental Sciences & Ecology [F08]
  • Sciences Du Vivant :: Sciences De L'Environnement & écologie [F08]
  • Human Health Sciences :: Pharmacy
  • Pharmacology & Toxicology [D20]
  • Sciences De La Santé Humaine :: Pharmacie
  • Pharmacologie & Toxicologie [D20]

Abstract

Sexually mature goldfish (Carassius auratus) of both sexes were exposed to two doses (100 and 1000 mug/l) of the widely used herbicide atrazine (2-chloro-4-ethylamino-6-isolropylamino-s-triazine) for a period of 21 days and effects on the concentrations of gonad and plasma sex steroids (testosterone (T), 17beta-estradiol (E2) and 11-ketotestosterone (11-KT)), plasma vitellogenin (VTG) and gonad histo-morphology assessed. Atrazine did not show any obvious estrogenic effect in males, as determined by a lack of vitellogenin induction. There were, however, effects of atrazine on plasma androgen concentrations (androgen dynamics) and tissue (plasma and gonad) estrogen concentrations in male goldfish; exposure to 1000 mug/l atrazine induced suppression in both testosterone and 11-ketotestosterone, and resulted in elevated 17beta-estradiol, after 21 day of exposure. Further, these suppressive effects on plasma androgens and the induction in estrogen were dose- and time-related. The highest atrazine exposure dose induced structural disruption in the testis and both 100 and 1000 mug/l induced elevated levels of atresia in ovaries. (C) 2003 Elsevier B.V. All rights reserved.

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