Affordable Access

Publisher Website

Bipolar disorder and metabolic syndrome: An international perspective

Authors
Journal
Journal of Affective Disorders
0165-0327
Publisher
Elsevier
Publication Date
Volume
126
Issue
3
Identifiers
DOI: 10.1016/j.jad.2010.04.012
Keywords
  • Bipolar Disorder
  • Metabolic Syndrome
Disciplines
  • Medicine

Abstract

Abstract Introduction The ubiquity and hazards posed by abnormal body composition and metabolic parameters in the bipolar population are a priority research and clinical issue. Herein, we summarize and synthesize international studies describing the rate of US National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III [ATP III])- and International Diabetes Federation (IDF)-defined metabolic syndrome and its criterion components in individuals with bipolar disorder. Methods We conducted a PubMed search of all English-language articles published between January 2005 and July 2009 with the following search terms: metabolic syndrome and bipolar disorder, mania and manic-depression. Articles selected for review were based on adequacy of sample size, the use of standardized experimental procedures, validated assessment measures, and overall manuscript quality. Results The rate of metabolic syndrome in individuals with bipolar disorder is increased relative to the general population. Disparate estimates are reported ranging from comparability to approximately twofold greater than the general population. The increased hazard for metabolic syndrome amongst bipolar individuals is now documented in twelve countries from Europe, Australia, Asia, North and South America. The co-occurrence of metabolic syndrome in the bipolar population is associated with a more complex illness presentation, less favourable response to treatment, and adverse course and outcome. The association between metabolic syndrome and bipolar disorder is mediated/moderated by both iatrogenic and non-iatrogenic factors. Discussion The increased hazard for metabolic syndrome in bipolar populations is due to the clustering of traditional (and emerging) risk factors as well as iatrogenic and health systems factors. Extant data support recommendations for prioritizing, surveillance, prevention, diagnosis and management of metabolic syndrome as routine care of the bipolar patient.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Metabolic Syndrome in Bipolar Disorders

on Indian Journal of Psychologica... Jan 01, 2012

International perspectives of pediatric bipolar di...

on Journal of the Canadian Academ... August 2009

The prevalence of metabolic syndrome in patients w...

on Journal of Affective Disorders Jan 01, 2008
More articles like this..