Affordable Access

Publisher Website

Effect of propranolol on ATP in human erythrocytes—Comparison with ouabain

Authors
Journal
Biochemical Medicine
0006-2944
Publisher
Elsevier
Publication Date
Volume
23
Issue
1
Identifiers
DOI: 10.1016/0006-2944(80)90056-3

Abstract

Abstract Propranolol enhanced utilization and generation of ATP in erythrocytes while ouabain suppressed both of them. After incubation of erythrocytes with propranolol, no change was noted in membrane ATPase activity while incubation with ouabain caused suppression of membrane ATPase. The effect of ouabain on erythrocyte ATP and lactate content is compatible with its inhibiting action of membrane ATPase activity. Propranolol may activate ATP-utilizing system(s) in the cytosol, or it may activate membrane ATPase activity only when combined with factor(s) lost during the preparation of the membrane. The above effect of propranolol may be unrelated to the β-adrenergic receptor blocking action since isoproterenol did not affect the erythrocyte ATP or lactate content and it did not counteract propranolol.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Effect of propranolol on ATP in human erythrocytes...

on Biochemical medicine February 1980

[Effects of propranolol and ouabain on ATP in eryt...

on Fukuoka igaku zasshi = Hukuoka... July 1979

[Effect of propranolol on ouabain-sensitive Na+,K+...

on Acta pharmaceutica Hungarica September 1989

Effect of propranolol on normal human erythrocytes...

on Journal of Laboratory and Clin... January 1977
More articles like this..