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Denervation induced changes in subcellular pools of 16S acetylcholinesterase activity from adult mammalian skeletal muscle

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
44
Issue
2
Identifiers
DOI: 10.1016/0304-3940(84)90079-x
Keywords
  • Acetylcholinesterase
  • Skeletal Muscle
  • Denervation
  • Subcellular Pools
  • Neural Regulation
  • Motor Endplate

Abstract

Abstract Acetylcholinesterase (AChE) inhibitors which differ in lipid solubility and thus in their ability to penetrate cell membranes were utilized to study the effects of denervation on discrete pools of 16S AChE from endplate regions of adult rat anterior gracilis muscle. Such pools have been interpreted as extra- and intracellular fractions of endplate 16S AChE activity. Denervation caused an almost immediate decay of intracellular 16S AChE, and a later (12–18 h) but roughly parallel decrease in its extracellular counterpart. Thus, the level at which the motor nerve exerts its primary regulatory influence on adult mammalian skeletal muscle endplate 16S AChE activity appears to be within muscle cells. This influence may affect the molecule's synthesis, assembly, and/or degradation.

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