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Serum γ-glutamyl transferase activity in chronic renal failure during regular heamodialysis and after successful renal transplantation

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
77
Issue
1
Identifiers
DOI: 10.1016/0009-8981(77)90405-3
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Serum γ-glutamyl transferase activity (γ-GT) was measured in 108 uraemic patients, 110 patients on regular haemodialysis and 71 successfully transplanted patients. The incidence of abnormal results was 11, 14 and 28%, respectively. The results in the non-dialyzed and dialyzed patients indicate that in uraemia serum γ-GT activity remains normal and as such, significant hepatic microsomal enzyme induction does not appear to occur. Raised serum γ-GT in uraemic patients and after renal transplantation should suggest concurrent, added, pathology such as hepatobiliary disease or the administration of hepatic microsomal enzyme inducing drugs.

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