Affordable Access

Publisher Website

Myofibrillar protein degradation and muscle proteinases in normal and diabetic rats

Authors
Journal
Biochemical Medicine
0006-2944
Publisher
Elsevier
Publication Date
Volume
21
Issue
1
Identifiers
DOI: 10.1016/0006-2944(79)90052-8
Disciplines
  • Biology

Abstract

Abstract In diabetic rats, the overall activities of alkaline proteinases and aminopeptidases in skeletal muscle are increased two- to three-fold. The elevation of proteolytic activities may be responsible for the massive breakdown of myofibrillar proteins indicated by a five-fold increase of 3-methylhistidine excretion into urine. Insulin treatment of the diabetic rats results in the normalization of both muscle proteolytic activities as well as the 3-methylhistidine excretion. Our data suggest that in diabetic rats the enhanced muscle protein catabolism is effected by the increased activities of alkaline proteinases and aminopeptidases and that insulin is a regulatory hormone of protein catabolism.

There are no comments yet on this publication. Be the first to share your thoughts.