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Behavioral and neurochemical modifications induced by apomorphine treatment

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
100
Identifiers
DOI: 10.1016/0304-3940(89)90696-4
Keywords
  • Apomorphine
  • Dopamine Receptor
  • Quantitative Autoradiography
  • Locomotion
  • Stereotypy

Abstract

Abstract By means of quantitative receptor autoradiography, the modifications of dopamine (DA) receptors in selected target regions of A 9 and A 10 DA neurons were studied after chronic apomorphine treatment, at a dosage able to induce behavioral changes that are claimed to be due to the activation of the target areas of A 9 neurons. An increase in [ 3H]spiperone binding sites (cold (+)-butaclamol) was observed in the dorsal and ventrolateral striatum, receiving fibers from A 9 neurons, while there were no changes in the ventromedial and ventrocentral striatum, in the nucleus accumbens and in the cerebral cortex receiving fibers from A 10 neurons. Our results suggest that the anatomical division of the DA target regions corresponds with a functional one.

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