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2,3-bisphosphoglycerate in erythroid cells

Authors
Journal
Trends in Biochemical Sciences
0968-0004
Publisher
Elsevier
Publication Date
Volume
7
Issue
4
Identifiers
DOI: 10.1016/0968-0004(82)90205-5
Disciplines
  • Biology
  • Medicine

Abstract

Abstract 2,3-Bisphosglycerate accumulates in erythrocytes where it facilitates the supply of oxygen to the tissues by binding to hemoglobin. The concentration of 2,3-bisphosphoglycerate changes in a number of physiological and pathological conditions and during animal ontogeny. During erythroid differentiation in bone marrow the synthesis of 2,3-bisphosphogylcerate is induced. The regulation of 2,3-bisphosphogylcerate metabolism is beginning to be understood.

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