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Caffeine-induced enhancement of chromosome damage in human lymphocytes treated with methyl-methanesulphonate, mitomycin C and X-rays

Authors
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
0027-5107
Publisher
Elsevier
Publication Date
Volume
23
Issue
3
Identifiers
DOI: 10.1016/0027-5107(74)90109-2

Abstract

Abstract Two hypothese have been put forward in the literature to explain the synergistic effect of caffeine with several mutagens: ( 1) binding of caffeine to DNA, and ( 2) inhibition of DNA repair. Autoradiographic studies with 3H- and 14C-labelled caffeine did not support the binding hypothesis. Caffeine enchanced in a synergistic way the amount of chromatid breaks and exchanged induced in human lymphocytes with methyl-methanesulphonate (MMS), mitomycin C (MC) and X-rays. The results are best explained if caffiene inhibits a post-replication repair process, particularly the filling-in of gaps in the newly synthesized DNA.

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