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Preparation, characterization and in vitro bioactivity of mesoporous bioactive glasses (MBGs) scaffolds for bone tissue engineering

Elsevier BV
Publication Date
  • 030300 Macromolecular And Materials Chemistry
  • 090400 Chemical Engineering
  • Mesoporous Materials
  • Bioactive Glasses
  • Scaffolds
  • Bioactivity
  • Tissue Engineering
  • Design
  • Engineering
  • Medicine
  • Physics


Bone and Tissue Regeneration Insights 2009:2 13–23 This article is available from © the authors, licensee Libertas Academica Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution and reproduction provided the original work is properly cited. Bone and Tissue Regeneration Insights 2009:2 13 Open Access Full open access to this and thousands of other papers at Bone and Tissue Regeneration Insights R e v I e w Tissue engineering Options for Ligament Healing Joseph w. Freeman School of Biomedical engineering and Sciences, virginia Tech, Blacksburg, vA, USA, 24060. email: [email protected] Abstract: The anterior cruciate ligament (ACL) is one of five ligaments in the knee that are important for stability and kinematics. It is also the most commonly injured ligament of the knee and due to its poor healing potential, severe damage warrants surgical intervention including complete replacement. Ligaments are longitudinally arranged, complex tissues; the mechanical properties of ligaments are a direct result of their components and the arrangement of these components in the tissue. It is these mechanics that have made ligaments so difficult to replace. Past ACL replacements have had many limitations that prevented their extensive use. These limitations range from mechanical fatigue over time to fraying of the device after implantation. In light of these problems, investigators have begun to pursue a host of new techniques to create a range of viable options for the repair, replacement, and/or regeneration of the ACL. These options include tissue engineered scaffolds with novel designs and specially treated transplanted tissues. In this article, the composition, arrangement, and mechanics of the ACL will be discussed in order to elucidate important aspects of ACL repair; past

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