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Insulin-like growth factor and interleukin-1β levels and subsequent fetal size in response to chronicPorphyromonas gingivalisexposure in the pregnant rabbit

Authors
Journal
American Journal of Obstetrics and Gynecology
0002-9378
Publisher
Elsevier
Publication Date
Volume
193
Issue
3
Identifiers
DOI: 10.1016/j.ajog.2005.05.039
Keywords
  • Porphyromonas Gingivalis
  • Rabbit
  • Pregnancy
  • Fetal Growth
Disciplines
  • Biology
  • Design

Abstract

Objective The purpose of this study was to describe maternal insulin-like growth factor, interleukin-1β, and fetal size in a rabbit model of Porphyromonas gingivalis exposure. Study design With the use of a previously described model, 8 New Zealand White rabbits were exposed to either P gingivalis or media during pregnancy and killed at term. Kit and placenta weight were compared between groups. Doe serum insulin-like growth factor system protein and interleukin-1β levels were compared by analysis of variance for repeated measures; a probability value of <.05 was considered to be significant. Results No significant differences in kit and placental weights between exposed and unexposed groups were observed. Insulin-like growth factor system proteins increased significantly as pregnancy progressed, but there were no significant differences in insulin-like growth factor system proteins or interleukin-1β between exposed and unexposed does. Conclusion Chronic P gingivalis exposure does not disrupt insulin-like growth factor system proteins or systemic inflammation and does not impair fetal growth in the pregnant rabbit. Gestational age changes in doe insulin-like growth factor system proteins occur, and the timing of exposure to oral pathogens may influence fetal growth.

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