Affordable Access

Publisher Website

Predicting microstructure development during casting of drug-eluting coatings

Authors
Journal
Acta Biomaterialia
1742-7061
Publisher
Elsevier
Publication Date
Volume
7
Issue
2
Identifiers
DOI: 10.1016/j.actbio.2010.09.019
Keywords
  • Microstructure
  • Coating
  • Modeling
  • Simulation
  • Diffusion
Disciplines
  • Chemistry
  • Computer Science
  • Design
  • Medicine
  • Philosophy

Abstract

Abstract We have devised a novel diffuse interface formulation to model the development of chemical and physical inhomogeneities, i.e. microstructure, during the process of casting drug-eluting coatings. These inhomogeneities, which depend on the coating constituents and manufacturing conditions, can have a profound affect on the rate and extent of drug release, and therefore the ability of coated medical devices to function successfully. By deriving the model equations in a time-dependent reference frame, we find that it is computationally viable to probe a wide, physically relevant range of material and process quantities. To illustrate the application of the model, we have evaluated the impact of manufacturing solvent, coating thickness and evaporation rate on microstructure development. Our results suggest that modifying these process conditions can have a strong and nearly discontinuous effect on coating microstructure, and therefore on drug release. Further, we demonstrate that the model can be applied to processes that involve the incremental application of the coating in layers or passes. This new model formulation, which can also be used to predict the kinetics of drug release, provides a tool to elucidate and quantify the relationships between process variables, microstructure and performance. Establishing these relationships can reduce empiricism in materials selection and process design, providing a facile and efficient means to tailor the underlying microstructure and achieve a desired drug-release behavior.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

[Recent developments of drug eluting stent coating...

on Yao xue xue bao = Acta pharmac... November 2011

Drug-eluting stent coatings.

on Wiley interdisciplinary review... 2009

Passive stent coatings in the drug-eluting era.

on The Journal of invasive cardio... April 2005

[Development of drug coating on drug eluting stent...

on Zhongguo yi liao qi xie za zhi... March 2006
More articles like this..