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The retinoblastoma protein pathway and the restriction point

Authors
Journal
Current Opinion in Cell Biology
0955-0674
Publisher
Elsevier
Publication Date
Volume
8
Issue
6
Identifiers
DOI: 10.1016/s0955-0674(96)80081-0
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract The emerging role of the retinoblastoma protein (pRb) as a major controller of the restriction point has been supported by recent discoveries, including pRb's ability to repress gene transcription by all three RNA polymerases, which suggests a link between DNA replication and cell growth. Convergent genetic and biochemical data provide new insights into the molecular events that are upstream of, at, and downstream of pRb phosphorylation, which is regulated by G 1-phase cyclins and cyclin-dependent kinases (Cdks) and their inhibitors (CKIs). Major advances have also been made in our understanding of a key role of the pathway involving cyclin D, Cdks, CKIs, pRb and E2F both in commitment to traversing the cell cycle and in restraining oncogenesis.

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