Affordable Access

Publisher Website

A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression

Authors
Journal
Current Opinion in Cell Biology
0955-0674
Publisher
Elsevier
Publication Date
Volume
7
Issue
5
Identifiers
DOI: 10.1016/0955-0674(95)80117-0

Abstract

Abstract A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hierarchies whose constituent inputs and outputs are constantly modulated by all the factors present in the cell's surrounding microenvironment. This is particularly evident in the mammary gland, where the construction and subsequent destruction of such a hierarchy regulates changes in tissue-specific gene expression, morphogenesis and apoptosis during each developmental cycle of pregnancy, lactation and involution.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

A hierarchy of ECM-mediated signalling regulates t...

on Current Opinion in Cell Biolog... October 1995

From laminin to lamin: regulation of tissue-specif...

on Trends in Cell Biology January 1995

From laminin to lamin: regulation of tissue-specif...

on Trends in Cell Biology Jan 01, 1995

Analysis of a tissue-specific enhancer: ARF6 regul...

on Molecular and Cellular Biology March 1992
More articles like this..