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Mapping of theCYP2JCytochrome P450 Genes to Human Chromosome 1 and Mouse Chromosome 4

Authors
Journal
Genomics
0888-7543
Publisher
Elsevier
Publication Date
Volume
49
Issue
1
Identifiers
DOI: 10.1006/geno.1998.5235
Disciplines
  • Biology

Abstract

Abstract CYP2J subfamily cytochromes P450 catalyze the NADPH-dependent oxidation of arachidonic acid to several unique eicosanoids that possess numerous biological activities including modulation of ion transport, control of bronchial and vascular smooth muscle tone, and stimulation of peptide hormone secretion. We have identified sequence variants in the 3′ untranslated regions of two mouse Cyp2jgenes ( Cyp2j5and Cyp2j6) and used a PCR-based oligonucleotide hybridization assay to map both genes to the central region of chromosome 4 distal to the Junoncogene. The corresponding human CYP2Jgene ( CYP2J2) has been assigned to human chromosome 1 on a panel of somatic hybrid cell lines and to 1p31.3–p31.2 by fluorescence in situhybridization analysis. The proximity of the Cyp2jcluster to the Cyp4acluster suggests that these genes may be part of a cassette of P450 genes involved in the oxidation of fatty acids.

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