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Systemic Delivery of Oncolytic Adenoviruses Targeting Transforming Growth Factor-β Inhibits Established Bone Metastasis in a Prostate Cancer Mouse Model

Authors
Journal
Human Gene Therapy
1043-0342
Publisher
Mary Ann Liebert
Publication Date
Volume
23
Issue
8
Identifiers
DOI: 10.1089/hum.2012.040
Keywords
  • Research Articles
Disciplines
  • Biology

Abstract

Hu and colleagues examine the effects of systemic administrations of oncolytic viruses expressing soluble transforming growth factor-β receptor II fused with human Fc (Ad.sTβRFc and TAd.sTβRFc) in a mouse model of prostate cancer bone metastasis. They show that infection of prostate tumor cells with these vectors leads to production of sTGFβRIIFc protein and that intravenous injection of Ad.sTβRFc and TAd.sTβRFc causes inhibition of skeletal tumor growth and tumor-induced hypercalcemia in vivo.

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