Publisher Summary Bovine spongiform encephalopathy (BSE) is a chronic neurological disease that appeared in British cattle in the 1980's following the introduction of a new form of winter feed also called “meat and bonemear” (MBM) produced from abattoir materials containing brain, spinal cord, pancreas, thymus, and intestines with their contents. However in 1996, a new disease was described occurring in Great Britain which resembled sporadic-CJD, but instead of affecting elderly patients, the disease seemed to be predominantly found among young people below the age of 40 years. The possibility was raised that it could have been caused by the consumption of B∼E-affected beef because it appeared from epidemiological studies that at least one million BSE-affected cattle had been slaughtered in abattoirs and entered the human food chain. This started the world hysteria about meat consumption. The USA then banned Americans from donating blood if they had been on holidays in Europe. The BSE problem continues to dominate public concern about food safety throughout the world.