Affordable Access

Publisher Website

The enhancement of selenite toxicity by methionine inEscherichia coli

Authors
Journal
Archives of Biochemistry and Biophysics
0003-9861
Publisher
Elsevier
Publication Date
Volume
99
Issue
3
Identifiers
DOI: 10.1016/0003-9861(62)90280-1

Abstract

Abstract The toxicity of SeO 3 −− to wild type Escherichia coli is enhanced by the presence of l-methionine in the growth medium. Data are presented which show that the same degree of toxicity is exhibited by the methionine-requiring mutant of E. coli, A.T.C.C. 9663. d-Methionine is shown to be ineffective. Exogenous methionine suppresses the biosynthesis of selenomethionine as well as methionine. The suppression of selenomethionine biosynthesis provides a basis for the enhanced toxicity of SeO 3 −−. It is also possible that the biosynthesis of selenocyst(e) ine may account for part of the enhanced toxicity. Interaction between SeO 3 −− and methionine as a basis for enhanced toxicity is unlikely from the data obtained on the methionine-requiring mutant, A.T.C.C. 9663.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

The enhancement of selenite toxicity by methionine...

on Archives of Biochemistry and B... December 1962

A comparison of selenite and tellurite toxicity in...

on Archives of Biochemistry and B... Jan 01, 1963

The effects of selenite on β-galactosidase inducti...

on Archives of Biochemistry and B... Jan 01, 1964

Quantitative studies on selenite metabolism inEsch...

on Archives of Biochemistry and B... Jan 01, 1968
More articles like this..