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INFLUENCE OF ACETYLSALICYLIC ACID, AN INHIBITOR OF PROSTAGLANDIN SYNTHESIS, ON THE DURATION OF HUMAN GESTATION AND LABOUR

Authors
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
302
Issue
7839
Identifiers
DOI: 10.1016/s0140-6736(73)92934-6

Abstract

Abstract A retrospective survey of 103 patients taking high-dose acetylsalicylic acid for at least the last 6 months of pregnancy has been carried out and comparisons made with control populations. Aspirin administration was associated with a highly significant increase in the average length of gestation, in the frequency of postmaturity, and in the mean duration of spontaneous labour. These observations are compatible with the known capacity of aspirin to inhibit the synthesis of prostaglandins, and suggest that endogenous prostaglandins are important regulators of the duration of human gestation and labour. The possibility is raised that aberrations in prostaglandin metabolism could be responsible for certain instances of postmaturity or prolonged labour.

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