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Endothelin Stimulates Protein Phosphorylation in Blood–Brain Barrier

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
219
Issue
2
Identifiers
DOI: 10.1006/bbrc.1996.0239
Disciplines
  • Biology

Abstract

Abstract The vasoactive neuropeptide endothelin stimulated phosphorylation of specific proteins in rat brain microvessels. Major effects were observed with endothelin-1. These effects were dose- and time-dependent. Among substrates for kinase actions, the 17.5 KDa and 80 KDa proteins were mainly affected by endothelin-1. It was demonstrated that the 80 KDa protein affected corresponds to MARCKS (myristoylated alanine-rich C kinase substrate), a specific substrate for protein kinase C action.

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