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Role of the β-amyloid precursor protein in Alzheimer's disease

Authors
Journal
Trends in Biochemical Sciences
0968-0004
Publisher
Elsevier
Publication Date
Volume
19
Issue
1
Identifiers
DOI: 10.1016/0968-0004(94)90173-2
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract Deposition of β-amyloid peptide in the brain is an early event in Alzheimer's disease, the most common cause of dementia. Studies of the β-amyloid precursor protein (APP), which gives rise to β-amyloid, are rapidly leading to a better understanding of the biochemical basis of the disease — a prerequisite for rational drug development.

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