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Assessing the effect of HAART on change in quality of life among HIV-infected women

BioMed Central
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  • Medicine

Abstract ral ss BioMed CentAIDS Research and Therapy Open AcceResearch Assessing the effect of HAART on change in quality of life among HIV-infected women Chenglong Liu1,2, Kathleen Weber3, Esther Robison4, Zheng Hu1, Lisa P Jacobson1 and Stephen J Gange*1 Address: 1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, 2Department of Medicine, Georgetown University School of Medicine, Washington, DC, USA, 3The CORE Center at John H. Stroger Jr Hospital of Cook County, Chicago, IL, USA and 4Montefiore Medical Center, New York, NY, USA Email: Chenglong Liu - [email protected]; Kathleen Weber - [email protected]; Esther Robison - [email protected]; Zheng Hu - [email protected]; Lisa P Jacobson - [email protected]; Stephen J Gange* - [email protected] * Corresponding author Abstract Background: The impact of highly active antiretroviral therapy (HAART) on health-related quality of life (QOL) of HIV-1 infected individuals in large prospective cohorts has not been well studied. Objective: To assess the effect of HAART on QOL by comparing HIV-infected women using HAART with HIV-infected women remaining HAART naïve in the Women's Interagency HIV Study (WIHS), a multicenter prospective cohort study begun in 1994 in the US. Methods: A 1:1 matching with equivalent (≤ 0.1%) propensity scores for predicting HAART initiation was implemented and 458 pairs were obtained. HAART effects were assessed using pattern mixture models. The changes of nine QOL domain scores and one summary score derived from a shortened version of the MOS-HIV from initial values were used as study outcomes. Results: The background covariates of the treatment groups were well-balanced after propensity score matching. The 916 matched subjects had a mean age of 38.5 years and 42% had a history of AIDS diagnosis. The participants contributed a total of 4,292 person visits with a median follow-up time of 4 years. In the bivariate analyses with only HA

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