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Expedient synthesis of α,α-difluorohomopropargylic alcohols from TIPS-difluorobromopropyne via a Zn-mediated propargylation of aldehydes and ketones

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
41
Issue
14
Identifiers
DOI: 10.1016/s0040-4039(00)00196-9

Abstract

Abstract The synthesis of α,α-difluorohomopropargyl alcohols containing an alkynyl silane moiety is reported. The title compound was prepared by the reaction of the organozinc derivative of TIPS-bromodifluoropropyne with aldehydes or ketones under mild conditions and in good yields.

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