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Haemolymph proteins of larvae ofGalleria mellonelladetoxify endotoxins of the insect pathogenic bacteriaXenorhabdus nematophilus(Enterobacteriaceae)

Authors
Journal
Journal of Insect Physiology
0022-1910
Publisher
Elsevier
Publication Date
Volume
43
Issue
11
Identifiers
DOI: 10.1016/s0022-1910(97)00072-3
Keywords
  • Galleria
  • Haemolymph
  • Proteins
  • Xenorhabdus
  • Endotoxins
Disciplines
  • Biology

Abstract

Abstract Haemolymph of non-vaccinated Galleria mellonella larvae contains two proteins, LBP-1 (17.2 kDa) and LBP-2 (26.0 kDa) that: 1. bond to the surfaces of the insect pathogenic bacteria, Xenorhabdus nematophilus; 2. prevented lipid A-binding dye attaching to the lipid A of X. nematophilus endotoxin; and 3. reduced endotoxin activity on the haemocytes. Protein LBP-1 also blocked the inhibition of prophenoloxidase activation by the endotoxins. It is proposed that proteins LBP-1 and LBP-2 are part of the containment responses of the insects to bacteria.

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