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Asymmetric synthesis of chiral synthons bearing alkynyl groupviaorganoaluminum-promoted pinacol-type rearrangement

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
27
Issue
3
Identifiers
DOI: 10.1016/s0040-4039(00)84022-8

Abstract

Abstract A method is described for the synthesis of chiral alkynyl ketones and alkynols via trimethylaluminum-promoted pinacol-type rearrangement where alkynyl groups behave as “the staying group”, followed by stereoselective reduction leading to the latter.

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