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STAT signaling in inflammation

Landes Bioscience
Publication Date
DOI: 10.4161/jkst.24198
  • Special Focus Letter From The Guest Editor
  • Biology
  • Medicine

Abstract JAK-STAT e24198-1 JAK-STAT 2:1, e24198; January/February/March 2013; © 2013 Landes Bioscience EdiTor’S cAornEr SpEciAL FocuS LETTEr FroM ThE guEST EdiTor Since their discovery, STAT proteins have been intimately tied to controlling the development of hematopoietic cells that regu- late inflammation, and mediating the responses of target cells to inflammatory cytokines. Although our understanding of STAT protein-dependent gene expression during inflammation has grown considerably over the past 15 years, the identification of new cell types that require STAT proteins for development, and new gene targets of STAT-dependent regulation, has added to the already complex network of cells and cytokines in immune- mediated diseases. The review articles in this special focus pro- vide perspective on a number of areas of recent research and highlight some of the next important questions in understanding how STAT proteins contribute to inflammatory disease. Inflammation can be broadly defined as the recruitment of lymphoid and myeloid cells to a site of injury or infection. Cytokines are integral to the development of inflammation and as a result, STAT proteins are critical mediators of immunity to pathogens, and in the development of inflammatory disease.1 Indeed, inflammation was one of the earliest biological functions associated with STAT proteins, from the anti-viral functions of STAT1, to the polarized T helper cell responses that required STAT4 and STAT6. In this special focus on STAT Signaling in Inflammation, six review articles by leading researchers describe the importance of STATs in immune responses, cellular develop- ment, and as targets for therapy of immune-mediated diseases. Although there is considerable work on how STAT proteins impact adaptive immunity, particularly in T helper cell develop- ment, less work has focused on innate responses and the devel- opment and function of innate immune cells. The reviews in this special focus

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