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Facile, chemoenzymatic synthesis of the potent antiviral compound, 2-acetonylinosine

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
46
Issue
7
Identifiers
DOI: 10.1016/j.tetlet.2004.12.065
Keywords
  • Regiospecific Functionalization
  • Enzyme-Mediated Synthesis
  • Antiviral Nucleoside
Disciplines
  • Medicine

Abstract

Abstract A facile and efficient methodology for the chemoenzymatic synthesis of the antiviral compound, 2-acetonylinosine has been developed. The present synthetic strategy, which has generality, is a dramatic improvement on the methodologies currently available for the synthesis of functionalized purine nucleosides of therapeutic interest.

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