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Pig–to–Non-human Primate Heart Transplantation: Immunologic Progress Over 20 Years

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
26
Issue
3
Identifiers
DOI: 10.1016/j.healun.2006.12.005
Keywords
  • Current Controversies
Disciplines
  • Medicine

Abstract

The major developments in pig–to–non-human primate heart xenotransplantation during the past 20 years are summarized, largely through the experience of one investigator. Genetic modifications to organ-source pigs have been important steps in increasing heart xenograft survival from a few minutes in 1986 to 2 to 6 months in 2005.

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