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The human and murine protocadherin-β one-exon gene families show high evolutionary conservation, despite the difference in gene number

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
495
Identifiers
DOI: 10.1016/s0014-5793(01)02372-9
Keywords
  • Protocadherin-β
  • Phylogeny
  • One-Exon Gene
  • Gene Family
Disciplines
  • Biology

Abstract

Abstract Extensive cDNA analysis demonstrated that all human and mouse protocadherin-β genes are one-exon genes. The protein sequences of these genes are highly conserved, especially the three most membrane-proximal extracellular domains. Phylogenetic analysis suggested that this unique gene family evolved by duplication of one single protocadherin-β gene to 15 copies. The final difference in the number of protocadherin-β genes in man (#19) and mouse (#22) is probably caused by duplications later in evolution. The complex relationship between human and mouse genes and the lack of pseudogenes in the mouse protocadherin-β gene cluster suggest a species-specific evolutionary pressure for maintenance of numerous protocadherin-β genes.

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