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Fas mRNA expression in blood is reduced during episodes of human corneal graft rejection.

Transplantation Journal
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
  • Adult
  • Genetics: Antigens
  • Cd95
  • Immunology: Corneal Transplantation
  • Blood: Graft Rejection
  • Humans
  • Middle Aged
  • Blood: Rna
  • Messenger
  • Research Support
  • Non-U.S. Gov'T
  • Medicine


BACKGROUND: Our purpose is to examine levels of Fas mRNA expression in blood during human corneal transplant rejection. METHODS: Fas mRNA expression was detected by reverse transcription-PCR in blood from normal controls, corneal recipients at the time of transplantation and during episodes of rejection. RESULTS: Samples taken at the time of a corneal rejection episode showed Fas mRNA levels were significantly lower in these patients than either normal controls (P = 0.017) or corneal transplant recipients not undergoing graft rejection (P = 0.00052). Serial samples from five patients who suffered an episode of rejection showed that the level of Fas mRNA is reduced during the rejection episode and subsequently recovers. CONCLUSIONS: These results indicate low levels of Fas mRNA in blood may have a role in corneal transplant rejection.

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