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An Orwellian Discourse on the Meaning and Measurement of Noninferiority

Authors
Journal
The American Journal of Cardiology
0002-9149
Publisher
Elsevier
Publication Date
Volume
99
Issue
2
Identifiers
DOI: 10.1016/j.amjcard.2006.07.090
Keywords
  • Editorial
Disciplines
  • Linguistics

Abstract

The customary interpretation of active-controlled noninferiority trials is founded on a number of unverifiable assumptions. These assumptions can be circumvented, and the semantic and statistic interpretation of the trials placed on a more rational foundation, if treatment comparisons are analyzed from a Bayesian perspective. In conclusion, the resultant probabilistic measures thereby render the meaning of noninferiority more transparent and clinically relevant.

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