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Study on the induction of spontaneous transmitter release at early nerve-muscle contacts inXenopuscultures

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
173
Identifiers
DOI: 10.1016/0304-3940(94)90141-4
Keywords
  • Synaptogenesis
  • Spontaneous Release
  • Spontaneous Synaptic Current
  • Acetylcholine
  • Induction
  • Calcium
  • Cell Culture

Abstract

Abstract During synaptogenesis, spontaneous acetylcholine release is rapidly induced by the contact of the growing neurite with the myocyte. Using Xenopus nerve-muscle co-cultures, we investigated the role of Ca 2+ in the presynaptic mechanisms mediating this induction process. We found that Ca 2+ influx is not necessary to induce spontaneous release and that an increase in cytosolic Ca 2+ is not sufficient to trigger this release in the absence of the target cell.

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