Affordable Access

Publisher Website

Neurobiological mechanisms by which nicotine mediates different types of anxiety

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
393
Identifiers
DOI: 10.1016/s0014-2999(99)00889-4
Keywords
  • Nicotine
  • 5-Ht1Areceptor
  • Anxiety
  • Phobia
  • Septum
  • Hippocampus
Disciplines
  • Biology
  • Chemistry

Abstract

Abstract The effects of nicotine administration into the dorsal hippocampus and lateral septum provide further evidence that different neurochemical and neuroanatomical substrates control behaviour in different animal tests. Thus, in the social interaction test (a model of generalised anxiety disorder), bilateral administration of nicotine (1–4 μg) into both regions has anxiogenic effects in test conditions that generate moderate anxiety. The anxiogenic effects are mediated by a nicotine-evoked increase in 5-hydroxytryptamine (5-HT) release and are reversed by co-administration of the 5-HT 1A receptor antagonist, N-(2-(6-(2-methoxyphenyl)-1-piperazinyl)ethyl)- N-(2-pyridyl)-cyclohexane carboxamide trichloride (WAY 100,635). On trial 1 in the elevated plus-maze (which models the escape components of panic disorder), nicotine is without effect when administered to the dorsal hippocampus, but has anxiogenic effects after lateral septal administration. On trial 2 in the elevated plus-maze (a model of specific phobia), nicotine (1 μg) has anxiolytic effects when administered to the dorsal hippocampus, but is ineffective (4 and 8 μg) in the lateral septum.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Neurobiological mechanisms by which nicotine media...

on European Journal of Pharmacolo... Mar 30, 2000

Neurobiological mechanisms of nicotine craving.

on Alcohol (Fayetteville, N.Y.) June 2001

[Neurobiological mechanisms of nicotine dependence...

on Italian heart journal : offici... April 2001
More articles like this..