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Assessment of the impact of hyperhomocysteinemia on bone using the methylenetetrahydrofolate reductase-deficient mouse model

McGill University
Publication Date
  • Biology
  • Genetics.


Bone strength was not decreased, and osteoclast numbers were not increased in heterozygotes or due to low folate. Expression levels of several genes involved in protection against oxidative stress were altered in heterozygotes as compared to wild-types. Bone mineral density was decreased and bone architecture changed as a result of low folate intake, especially in heterozygotes. These findings shed light on possible mechanisms of homocysteine toxicity in bone.

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