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Excitatory amino acids as transmitter candidates of vibrissae afferent fibres to the rat trigeminal nucleus caudalis

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
22
Issue
2
Identifiers
DOI: 10.1016/0304-3940(81)90085-9

Abstract

Abstract Responses of single neurones to vibrissal stimulation and to the iontophoretically applied putative neurotransmitters, l-glutamate and l-aspartate, were recorded in the trigeminal nucleus caudalis of the rat. Vibrissal responses were unaffected by the specific N-methyl- d-aspartate receptor antagonist, d-α-aminoadipate, but were antagonized by the broad-spectrum amino acid antagonist cis-2,3-piperidine dicarboxylate. These findings suggest that the neurotransmitter of vibrissae afferent fibres may be an endogenous excitatory amino acid acting at a receptor other than the N-methyl- d-aspartate receptor.

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