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The structure and function of glycoprotein hormone receptors: Ganglioside interactions with human chorionic gonadotropin

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
73
Issue
2
Identifiers
DOI: 10.1016/0006-291x(76)90717-8

Abstract

Abstract Gangliosides inhibit the binding of 125I-labeled human chorionic gonadotropin to rat testes membranes. The inhibition is the result of an interaction between the hormone and the ganglioside rather than the membrane and ganglioside, and the interaction with the ganglioside can be detected by fluorescence spectroscopy. In both the binding inhibition and fluorescence studies, human chorionic gonadotropin recognizes an oligosaccharide sequence on the ganglioside molecule distinct from the sequence recognized by thyrotropin.

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