Affordable Access

Local power for synapses

The Rockefeller University Press
Publication Date
DOI: 10.1083/jcb1705rr5
  • News
  • Research Roundup
  • Biology


1705rr Research Roundup JCB • VOLUME 170 • NUMBER 5 • 2005698 The early neurite gets the axon developing neuron sprouts many neurites, only one of which will become the axon, while the rest form dendrites. Axon choice has been thought to result from competition among neurites, possibly for a growth promoter. But now, Froylan Calderon de Anda, Guilia Pollarolo, Jorge Santos Da Silva, Carlos Dotti, and colleagues (Universita degli Studi di Torino, Italy) show that the location of the axon is deter- mined before most neurites form. By the time the first neurite forms, the group finds, it already marks the location of the axon. No one has seen this association before because they have been looking at stage 2 neurons, which have already formed many neurites. “To find the specific molecular events that are instructions for polarity,” says Dotti, “we should look at the immediate postmitotic stage, even before neurites form.” At this stage, the centrosome and Golgi apparatus still sit on the opposite end of the cell from the site of cytokinesis. It was here, near the centrosome, where the first lamellipod (and thus the first neurite) formed. Polarized membrane trafficking was aimed at the plasma membrane near the centrosome. This polar- ization might be a result of mechanical deformation of the membrane by centrosome-organized microtubules (perhaps as a continuation of cytokinetic forces). Or it might be due to the A local destabilization of actin filaments (which promotes membrane fusion events) by pericentrosomal proteins. The first neurite is expected to receive the most external growth cues, given a uniform environment, and thus would be the first to reach any threshold that leads to axon commitment. Cells with two centrosomes—and therefore two early neurites— formed two axons. Loss of centrosomal function, in contrast, blocked axon formation and led only to dendrites. Not long after mitosis, the centrosome changes its position, so it is easy to imagine

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

On the power of non-local boxes

on Theoretical Computer Science Jan 01, 2006

Nurses win local power.

on Nursing times 2011
More articles like this..