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Conformational analysis by NMR of an analogue of thyrotropin releasing factor: The tripeptide «GLU-LEU-PRO-A

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
65
Issue
4
Identifiers
DOI: 10.1016/s0006-291x(75)80384-6

Abstract

Summary The 270 MHz Proton magnetic resonance spectra of Leu 2-TRF in various solvents have been analyzed. The spectral features show that this analog of TRF exhibits in solution an as great conformational freedom as the hormone. Our study indicates that the molecule undergoes conformational changes with solvent and identifies the sections of the peptide involved in the rearrangements.

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