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Lack of biofilm contribution to bacterial colonisation in an experimental model of foreign body infection byStaphylococcus aureusandStaphylococcus epidermidis

Authors
Journal
FEMS Immunology & Medical Microbiology
0928-8244
Publisher
Oxford University Press
Publication Date
Volume
35
Issue
2
Identifiers
DOI: 10.1016/s0928-8244(02)00463-7
Keywords
  • Foreign Body Infection
  • Staphylococcus Aureus
  • Staphylococcus Epidermidis
  • Biofilm
  • Icagene

Abstract

Abstract The contribution of in vivo biofilm-forming potential of Staphylococcus aureus and Staphylococcus epidermidis was studied in an experimental model of foreign body infections. Increasing inocula (from 10 2 to 10 7 organisms) of ica-positive strains of S. aureus and S. epidermidis and their ica-negative isogenic mutants (the ica locus codes for a major polysaccharide component of biofilm) were injected into subcutaneously implanted tissue cages in guinea pigs. Surprisingly, bacterial counts and time-course of tissue cage infection by ica-positive strains of S. aureus or S. epidermidis were equivalent to those of their respective ica-negative mutants, in the locally infected fluids and on tissue-cage-inserted plastic coverslips.

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