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An improved method for anchoring of 9-fluorenylmethoxycarbonyl-amino acids to 4-alkoxybenzyl alcohol resins.

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
28
Issue
49
Identifiers
DOI: 10.1016/s0040-4039(00)61832-4

Abstract

Abstract Esterification of Fmoc-amino acids to 4-alkoxybenzyl alcohol polystyrene by 2,6-dichlorobenzoyl chloride represents a convenient method. It is free of the two side-reactions observed with dicyclohexylcarbodiimide/ 4-dimethylaminopyridine, viz. racemization and dipeptide formation.

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