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Solution-phase synthesis of a 1,5-dialkylamino-2,4-dinitrobenzene library and the identification of novel antibacterial compounds from this library.

Authors
Type
Published Article
Journal
Journal of Combinatorial Chemistry
1520-4766
Publisher
American Chemical Society
Volume
2
Issue
5
Pages
467–474
Source
Kit Lam Lab

Abstract

In this report we demonstrate that a 1,5-dialkylamino-2,4-dinitrobenzene small molecule library can be generated by a highly efficient solution-phase synthesis method. From this 2485-member library, a series of novel compounds with antibacterial activity were isolated. The significance of this report is that the synthetic scheme is extremely simple, with minimal number of liquid handling steps, and the solvents and reagents left in the final library preparation are fully compatible with cell-based assays.

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