Affordable Access

Publisher Website

Immunohistochemical detection of neural cell adhesion molecule and laminin in x-linked dystrophic dogs and mdx mice

Authors
Journal
Journal of Comparative Pathology
0021-9975
Publisher
Elsevier
Publication Date
Volume
110
Issue
3
Identifiers
DOI: 10.1016/s0021-9975(08)80278-2
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Summary Although dystrophin deficiency is known to be the genetic and biochemical defect causing Duchenne muscular dystrophy (DMD), much remains unknown about the underlying factors affecting clinical and pathological expression of the disease. Two animal forms of muscular dystrophy resembling DMD have been described. Neural cell adhesion molecule (NCAM) and laminin expression were examined in the proliferation-competent mdx mouse and non-regenerative "golden retriever muscular dystrophy dog" (GRMD). The results showed that (1) NCAM expression was greater in dystrophic dogs and mice than in age-matched normal animals, (2) myoblast-specific NCAM was greater in mdx mice than in dystrophic dogs, and (3) laminin strongly labelled mdx and GRMD myofibre membranes but was also sometimes found in individual interstitial cells of mdx muscle. Expression of these proteins may partly determine the clinicopathological expression of dystrophin deficiency.

There are no comments yet on this publication. Be the first to share your thoughts.