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Impaired cognitive function in healthy offspring of bipolar patients

Annals of General Psychiatry
Springer (Biomed Central Ltd.)
Publication Date
DOI: 10.1186/1744-859x-9-s1-s159
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Impaired cognitive function in healthy offspring of bipolar patients MEETING ABSTRACT Open Access Impaired cognitive function in healthy offspring of bipolar patients Agnieszka Permoda-Osip1*, Alina Borkowska2, Janusz K Rybakowski1 From 1st International Congress on Neurobiology and Clinical Psychopharmacology and European Psychiatric Association Conference on Treatment Guidance Thessaloniki, Greece. 19-22 November 2009 Background Several recent papers report on impaired of cognitive functions in healthy offspring of patients with bipolar mood disorder [1-3]. The aim of this study was an assessing of the performance on the Wisconsin Card Sorting Test (WCST), measuring executive functions, in the offspring of bipolar patients compared with gender- and age matched healthy subjects. Materials and methods Fifty persons (17 male, 33 female), aged 18-52 (30 ± 7) years made the total adult offspring population of patients with bipolar mood disorder. Among them, two had a history of depressive episodes, and another eight scored positively on Mood Disorder Questionnaire [4]. The head-to-head age- and gender-matched healthy subjects were used as a comparison group. The compu- ter version of WCST designed by Heaton et al. (1993) adapted with instructions in Polish was used in all sub- jects. The following domains of WCST were measured: the percentage of perseverative errors (WCST-P), the percentage of non-perseverative errors (WCST-NP), the number of correctly completed categories (WCST-CC), the percentage of conceptual level responses (WCST-% conc), and the set to the first category (WCST-1st cat). Results The results in the total offspring group were signifi- cantly inferior compared to matched control group in the categories of perseverative errors (WCST-P) and conceptual responses (WCST-%conc). These differences remained significant after Bonferroni correction. The offspring of patients with some affective morbidity (n = 10) did not show differences with forty healthy patients. Concl

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